Santa Fe is a third class municipality in the province of Nueva Vizcaya, Philippines. According to the 2010 census, it has a population of 14,427 people. It is the only town that borders Pangasinan.
This town is a typical bus stop for commuters going to the provinces of Isabela and Cagayan. This town is the end point of the Dalton Pass, a zig zag road from San Jose to Carranglan, Nueva Ecija. Local products include brooms, strawberry jam, strawberry wine, peanut butter, orchids and quilts.